Tumor volume in  550 verwijderde prostaten in Rotterdam
minimale tumor =  <0.5 ml, Gleason <7
54 % van door screening ontdekte tumoren zou gwoonlijk niet ontdekt worden (Draisma 2003)
Overdiagnosis does not exist……

No pattern 4 or 5, less than 2 positive cores
So in nearly 70 % of men with PSA < 3 minimal tumours are found that might be non-threatening
This corresponds with the estimated lead time and calculated overdiagnosis

In round 2 less tumours are detected (40 % of round 1), tumours are smaller, and minimal tumours are more frequent. This reflects more the ultimate status of the population after the first selection